Inoculation theory was developed by social psychologist William J. McGuire in 1961 to explain more about how attitudes and beliefs change, and more importantly, how to keep existing attitudes and beliefs consistent in the face of persuasion attempts. Inoculation theory continues to be studied today by communication, social psychology, and other social science researchers. The theory has been proposed and assessed in various contexts, including politics (e.g., Pfau et al., 1990; see Compton & Ivanov, 2013, for a review), environment (van der Linden, Leiserowitz, Rosenthal, & Maibach, 2016), health campaigns (e.g., Pfau & VanBockern, 1994; see Compton, Jackson, & Dimmock, 2016, for a review), marketing (e.g., Compton & Pfau, 2004), education (Compton, 2011), among others. ( See Banas & Rains, 2010, for a meta-analysis, and Compton, 2013, for a narrative overview.)
Inoculation can best be explained by a medical inoculation analogy. Indeed, the analogy served as the inaugural exemplar for how inoculation confers resistance. As McGuire (1961) initially explained, a medical inoculation works by exposing a body to weakened viruses—strong enough to trigger a response (i.e., the production of antibodies), but not so strong as to overwhelm the body's resistance. Attitudinal inoculation seems to work the same way: Expose someone to weakened counterarguments, triggering a process of counterarguing which eventually confers resistance to later, stronger persuasive messages.
The idea of inoculation was derived from previous research studying one-sided and two-sided messages. One-sided messages are supportive messages to strengthen existing attitudes, but with no mention of counterpositions. Two-sided messages present both counterarguments and refutations of those counterarguments (Lumsdaine & Janis, 1953).
One of the greatest motivators for McGuire was the aftermath of the Korean War. Nine US prisoners of war, when given the opportunity, elected to remain with their previous captors. Many assumed they were brainwashed, so McGuire and other social scientists turned to ways of conferring resistance to persuasion. This was a change in persuasion research, which was almost exclusively concerned with how to make messages more persuasive, and not the other way around (Gass & Seiter, 2003).
McGuire led a series of experiments assessing inoculation's efficacy and adding nuance to our understanding for how it works (for a review, see Compton, 2013; Compton & Pfau, 2005). The early studies (e.g., McGuire & Papageorgis, 1961) limited testing of inoculation theory to cultural truisms, or beliefs accepted without consideration (e.g., people should brush their teeth daily.) Later development of the theory extended inoculation to more controversial and contested topics in the contexts of politics (see Compton & Ivanov, 2013), health (see Compton, Jackson, & Dimmock, 2015), marketing, and contexts in which people have different pre-existing attitudes, such as climate change. The theory has also been applied in education to help prevent substance abuse.