Indian Creek is a stream in Pike County of northeastern Missouri. It is a tributary of North Fork Cuivre River.
The stream source is at 39°20′42″N 91°23′00″W / 39.34500°N 91.38333°W and the confluence is at 39°10′06″N 91°11′06″W / 39.16833°N 91.18500°WCoordinates: 39°10′06″N 91°11′06″W / 39.16833°N 91.18500°W.
Indian Creek was so named for the fact mound-building Indians once settled the area.