Imagawa Ujizane (今川 氏真?, 1538 – January 27, 1615) was a Japanese daimyō who lived in the Sengoku through early Edo periods. He was the tenth head of the Imagawa clan, and was a son of Imagawa Yoshimoto and the father of Imagawa Norimochi and Shinagawa Takahisa.
Ujizane was born in Sunpu Domain; he was the eldest son of Imagawa Yoshimoto. In 1554, he married the daughter of Hōjō Ujiyasu (Lady Hayakawa) as a means of cementing the three-way alliance between the Imagawa, Takeda, and Hōjō clans. Ujizane inherited family headship in 1558, when his father retired in order to focus his attention on the Imagawa advance into Tōtōmi and Mikawa Provinces.
After Yoshimoto's death Imagawa Ujizane was attacked by Shingen and Ieyasu.
After the 1569 Siege of Kakegawa, Imagawa Ujizane allied himself with Ieyasu in return for help in recovering his territory in Suruga Province.
Ujizane later retaliated against the landlocked Takeda clan with a salt embargo. This had little effect because Uesugi Kenshin took the opportunity to sell salt to the Takeda, and only resulted in the downfall of the Imagawa clan. He enjoyed playing Kemari and poetry.