Ikoma Masatoshi (生駒 正俊?, 1586 – July 23, 1621) was a Japanese samurai of the late Azuchi-Momoyama period, who lived into the early Edo period. He was also the daimyo of the Takamatsu Domain.
Masatoshi fought at the Siege of Osaka in 1614, commanding a detached force on the side of the Tokugawa.
After his death, he was succeeded as family head by his son, Takatoshi.