"I Can't Stand It" was the first single from Eric Clapton's 1981 album Another Ticket. On the record label for the vinyl 45, its credited as Eric Clapton and His Band. It was also used for interludes on Bill O'Reilly's radio show, The Radio Factor.

AllMusic critic Matthew Greenwald recalls the song as "one of Eric Clapton's biggest hits from the early '80s" and found "this song found him continuing, in his words, to be as much a musicologist as a musician." Greenwald goes on to saying that the songs "lyrics have a venomous jealousy, and they are some of Clapton's most literate of the period". He rounded his review up by saying that "musically, some classic, almost Booker T. & the M.G.'s-styled chord changes highlight the driving tempo, providing Clapton with a huge hit". William Ruhlman of AllMusic recalls that I Can't Stand It "held up well".

Besides becoming a pop hit in its own right, reaching No. 10 on the Billboard Hot 100, it was also the first No. 1 song on Billboard's Top Tracks chart for rock songs, which debuted in March 1981. It stayed at the summit for two weeks. The song reached #15 in Canada. By 1981, Broadcast Music, Inc. measured more than one million broadcasts of the song, earning Clapton a special recognition certificate.

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