ISA (Days of Our Lives)

The International Security Alliance (ISA) is a fictional intelligence agency on the soap opera Days of Our Lives. A highly secretive organization, its agents have been operating in the small Midwestern town of Salem at least since its first appearance on the show in the early 1980s (although several characters' histories indicate involvement well back into the mid-to-late 1970s).

Several of Salem's more prominent citizens have served at one time or another as agents for the ISA, including Roman Brady, Philip Kiriakis, Shane Donovan, Steve Johnson, Gabrielle Pascal, John Black, Billie Reed, and Rafe Hernandez. Others such as Bo Brady, Hope Brady, Kimberly Brady, Diana Colville, and Marlena Evans, while not full-fledged agents, have assisted (willingly or unwillingly) in the agency's operations.

The agency was originally portrayed as a multinational crime-fighting task force, well-funded but relatively informal and highly secretive, with agents and operations in every country of the Western world. As time progressed, the ISA was fleshed out into a full-fledged government agency, presumably American although many agents have been British. Although now purportedly an intelligence or "spy" agency, the ISA's mandate still generally appears to be centered on criminal investigations rather than political espionage, with a specialty in the sort of high-level, international criminal activities that has tended to center in the otherwise quiet town of Salem -- such as those controlled by the DiMera, Kiriakis, and Alamain families.

...
Wikipedia