Hydroxytyrosol
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IUPAC name
4-(2-Hydroxyethyl)-1,2-benzenediol
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| Other names
3-Hydroxytyrosol
3,4-dihydroxyphenylethanol (DOPET) Dihydroxyphenylethanol 2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) 3,4-dihydroxyphenolethanol (3,4-DHPEA) |
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| Identifiers | |
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3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.114.418 |
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PubChem CID
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| UNII | |
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| Properties | |
| C8H10O3 | |
| Molar mass | 154.163193 g/mol |
| Appearance | Clear, faint yellow to yellow liquid |
| Boiling point | 174 °C (345 °F; 447 K) |
| 5 g/100 ml (25 °C) | |
| Hazards | |
| Main hazards | Causes skin irritation.
Causes serious eye irritation. May cause respiratory irritation. |
| Safety data sheet | [1] |
| R-phrases (outdated) | R36/37/38 |
| S-phrases (outdated) | S26, S37/39 |
| Related compounds | |
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Related alcohols
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ethanol, phenol, tyrosol |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 (what is   ?) |
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| Infobox references | |
Causes serious eye irritation.
May cause respiratory irritation.
Hydroxytyrosol is a phenylethanoid, a type of phenolic phytochemical with antioxidant properties in vitro. In nature, hydroxytyrosol is found in olive leaf and olive oil, in the form of its elenolic acid ester oleuropein and, especially after degradation, in its plain form.
Hydroxytyrosol itself in pure form is a colorless, odorless liquid. The olives, leaves and olive pulp contain large amounts of hydroxytyrosol (compared to olive oil), most of which can be recovered to produce hydroxytyrosol extracts. However, it was found that black olives, such as common canned variety, containing iron(II) gluconate contained very little of the original hydroxytyrosol, as iron salts are catalysts for its oxidation.
Hydroxytyrosol can also be produced endogenously as it is a product of dopamine oxidative metabolism known as DOPET (3,4-dihydroxyphenylethanol).
Hydroxytyrosol is mentioned by the scientific committee of the European Food Safety Authority as one of several olive oil polyphenols that may contribute to protecting blood lipids against oxidation.
As of 2015, the NOAEL for hydroxytyrosol in rats is 250 mg/kg/day, with a LOAEL of 500 mg/kg/day.
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