Sir Humphrey de Trafford, 2nd Baronet (1 May 1808 – 4 May 1886) was a prominent English Catholic. Born at Croston Hall near Chorley, Lancashire on 1 May 1808, he was the fourth child and the eldest son of Sir Thomas de Trafford.
In 1821 he was entered as a pupil at the Manchester Grammar School and became a boarder in the high master's house. He also studied at Oscott College, a Catholic seminary. In 1826 he entered the Royal Dragoons, becoming a lieutenant in 1830, and retiring in 1832. He is recorded as having placed the last keystone in position for the Victoria Bridge, connecting Manchester and Salford across the River Irwell, on 23 March 1839. On the death of his father, on 10 November 1852, he became the 2nd Baronet de Trafford, 25th Lord of Trafford, and took up residence at the family home of Trafford Hall, in Trafford Park.
On 17 January 1855, he married Lady Annette Mary Talbot, eldest sister and co-heiress of Bertram Talbot, 17th Earl of Shrewsbury. The ceremony took place in Rugby, Worcestershire, and was performed by William Bernard Ullathorne, Bishop of Birmingham. It was reportedly the first Roman Catholic nuptial mass to be performed in England since the Reformation. They had five daughters and three sons:
The national land survey of 1873 records Sir Humphrey as holding 1,990 acres (810 ha) of land in Cheshire, producing an annual gross rental income of £3,361. In 1861 he served as High Sheriff of Lancashire