Humphrey Weld (died 29 November 1610) was an English merchant who was Lord Mayor of London in 1608.
Weld was a city of London merchant and a member of the Worshipful Company of Grocers. On 9 May 1598, he was elected an alderman of the City of London for Farringdon Within ward. He was Sheriff of London from 1599 to 1600. He was knighted on 26 July 1603. He became alderman for Walbrook ward in 1604. In 1608, he was elected Lord Mayor of London. He was president of Christ's Hospital from 1609.
Weld married Ann Wheler (daughter of Nicolas Wheler), the mother of his children and then a daughter of Sir Stephen Slaney, Lord Mayor for 1595 to 1596. His grandson, also named Humphrey Weld, bought Lulworth Castle and the surrounding estates in 1641.