Since the discovery of ionizing radiation, a number of human radiation experiments have been performed to understand the effects of ionizing radiation and radioactive contamination on the human body, specifically with the element plutonium.
Numerous human radiation experiments have been performed in the United States, many of which were funded by various U.S. government agencies such as the United States Department of Defense and the United States Atomic Energy Commission. Experiments included, but were not limited to:
On January 15, 1994, President Bill Clinton formed the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by Ruth Faden, Ph.D., MPH of the Johns Hopkins Berman Institute of Bioethics. One of the primary motivating factors behind his decision to create ACHRE was action taken by his newly appointed Secretary of Energy, Hazel O’Leary, J.D. One of her first actions on taking the reins of the Department of Energy was to announce a new openness policy for the Department. The policy led almost immediately to the release of over 1.6 million pages of classified records. The records made clear that since the 1940s the Atomic Energy Commission had been sponsoring tests on the effects of radiation on the human body. American citizens who had checked into hospitals for a variety of ailments were secretly injected with varying amounts of plutonium and other radioactive materials without their knowledge. Ebb Cade was an unwilling participant in medical experiments that involved injection of 4.7 micrograms of Plutonium on 10 April 1945 at Oak Ridge, Tennessee. This experiment was under the supervision of Harold Hodge. Most patients thought it was "just another injection," but the secret studies left enough radioactive material in many of the patients' bodies to induce life-threatening conditions. Such experiments were not limited to hospital patients, but included other populations such as those set out above, e.g., orphans fed irradiated milk, children injected with radioactive materials, prisoners in Washington and Oregon state prisons. Much of the experimentation was carried out in order to assess how the human body metabolizes radioactive materials, information that could be used by the Departments of Energy and Defense in Cold War defense/attack planning.