Human herpesvirus 7

Human herpesvirus 7
Classification and external resources
ICD-9-CM	058.12
DiseasesDB	5863
MeSH	D016199
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Human herpesvirus 7
Virus classification
Group:	Group I (dsDNA)
Order:	Herpesvirales
Family:	Herpesviridae
Subfamily:	Betaherpesvirinae
Genus:	Roseolovirus
Species
Human herpesvirus 7 (HHV-7)

Human herpesvirus 7 (HHV-7)

Human herpesvirus 7 (HHV-7) is one of nine known members of the Herpesviridae family that infects humans. HHV-7 is a member of Betaherpesviridae, a subfamily of the Herpesviridae that also includes HHV-6 and cytomegalovirus (HHV-5 or HCMV). HHV-7 often acts together with HHV-6, and the viruses together are sometimes referred to by their genus, Roseolovirus. HHV-7 was first isolated in 1990 from CD4+ T cells taken from peripheral blood lymphocytes.

Both HHV-6B and HHV-7, as well as other viruses, can cause a skin condition in infants known as exanthema subitum, although HHV-7 causes the disease less frequently than HHV-6B. HHV-7 infection also leads to or is associated with a number of other symptoms, including acute febrile respiratory disease, fever, rash, vomiting, diarrhea, low lymphocyte counts, and febrile seizures, though most often no symptoms present at all.

There are indications that HHV-7 can contribute to the development of drug-induced hypersensitivity syndrome,encephalopathy,hemiconvulsion-hemiplegia-epilepsy syndrome,hepatitis infection, postinfectious myeloradiculoneuropathy,pityriasis rosea, and the reactivation of HHV-4, leading to "mononucleosis-like illness".

Complications with HHV-7 infection has been shown to be a factor in a great variety of transplant types.

A mature virus particle measures about 170 nanometres (1,700 Å) in diameter.

The genome of HHV-7 is very similar to that of HHV-6, although it is about 10% smaller, with a DNA genome of about 145,000 base pairs. There are a number of key differences between the genome of HHV-7 and that of HHV-6, but the importance of them for viral DNA replication is not yet known.

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