Human Genome Sequencing Center

The Baylor College of Medicine Human Genome Sequencing Center (BCM-HGSC) was established by Richard A. Gibbs in 1996 when Baylor College of Medicine was chosen as one of six worldwide sites to complete the final phase of the international Human Genome Project. Gibbs is the current director of the BCM-HGSC.

It occupies more than 36,000 square feet (3,300 m²), employing over 200 staff, including eighteen faculty, and is one of three National Institutes of Health funded genome centers that were involved in the completion of the first human genome sequence in 2004. The BCM-HGSC contributed approximately 10 percent of the total project by sequencing chromosomes 3, 12 and X. The BCM-HGSC collaborated with researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory and Celera Genomics to sequence the first species of fruit fly, Drosophila melanogaster. The BCM-HGSC also completed the second species of fruit fly (Drosophila pseudoobscura), the honeybee (Apis mellifera), and led an international consortium to sequence the brown Norway rat.

The Human Genome Sequencing Center subsequently sequenced and annotated the genome of the cow (Bos taurus), the sea urchin, rhesus macaque, tammar wallaby, Dictyostelium discoideum, and a number of bacteria that cause serious infections (Rickettsia typhi, Enterococcus faecium, Mannheimia haemolytica, and Fusobacterium nucleatum). The BCM-HGSC was a major contributor to the Mammalian Gene Collection program, to sequence all human cDNAs, as well as the International Haplotype Mapping Project (HapMap).

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