Hugh Pelham
| Sir Hugh Pelham | |
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| Born | Hugh Reginald Brentnall Pelham 26 August 1954 |
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| Thesis | Transcription and Translation in Reticulocyte Lysates (1978) |
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| Spouse | Mariann Bienz (m. 1996) |
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Sir Hugh Reginald Brentnall Pelham (born 1954)FRS FMedSci is a cell biologist who has contributed to our understanding of the body’s response to rises in temperature through the synthesis of heat shock proteins. He has been the Director of the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge since 2006.
Pelham was educated at Marlborough College in Marlborough, Wiltshire and Christ's College, Cambridge. He graduated with a Master of Arts degree in Natural Sciences followed by a PhD for research on transcription and translation in immature blood cells (Reticulocytes). His PhD was supervised by Richard J. Jackson and Tim Hunt, who went on to receive the Nobel Prize in Physiology or Medicine in 2001.
Pelham is one of the foremost authorities on the movement of proteins within cells. Pelhams’s work has explained how some proteins can protect cells from damage. He has also shown how cells remove damaged or unwanted proteins — vital for maintaining their healthy functioning. More recently, his research investigates how proteins are modified and sorted to their correct places within cells and aims to find ways of blocking these processes.
Pelham been a visiting professor at the University of Zurich and held many posts at the Laboratory of Molecular Biology in Cambridge, where he succeeded Richard Henderson to become the LMB's Director in 2006.
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