"How Can I Ease the Pain" is a song by American singer Lisa Fischer, from her album So Intense. It was produced by Narada Michael Walden and Louis Biancaniello. The hit song spent two weeks at number-one on the U.S. Billboard Hot R&B/Hip-Hop Songs chart. The song was sampled by rap group Three 6 Mafia for their hit "Late Nite Tip".

In 1992 the single won a Soul Train Music Award for Best R&B/Soul Single, Female and it also won a 1992 Grammy Award for Best Female R&B Vocal Performance. The song also peaked at number eleven on the pop charts. This was Fischer's biggest and most well-known hit.