*** Welcome to piglix ***

Homovanillic acid

Homovanillic acid
Structural formula of homovanillic acid
Ball-and-stick model of the homovanillic acid molecule
Names
Preferred IUPAC name
(4-Hydroxy-3-methoxyphenyl)acetic acid
Other names
2-(4-Hydroxy-3-methoxyphenyl)acetic acid; 3-Methoxy-4-hydroxyphenylacetic acid; 4-Hydroxy-3-methoxy-benzeneacetic acid
Identifiers
3D model (Jmol)
ChEBI
ChemSpider
ECHA InfoCard 100.005.616
KEGG
MeSH Homovanillic+acid
PubChem CID
Properties
C9H10O4
Molar mass 182.18 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY  (what is YesYN ?)
Infobox references

Homovanillic acid (HVA) is a major catecholamine metabolite and is produced by the consecutive action of monoamine oxidase and catechol-O-methyl transferase on dopamine. It is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.

In psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose. HVA presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

Fasting plasma levels of HVA are known to be higher in females than in males. This does not seem to be influenced by adult hormonal changes, as the pattern is retained in the elderly and post-menopausal as well as transgender people according to their genetic sex, both before and during cross-sex hormone administration. Differences in HVA have also been correlated to tobacco usage, with smokers showing significantly lower amounts of plasma HVA.


...
Wikipedia

...