"Hit the Road Jack" is a song written by the rhythm and blues artist Percy Mayfield and first recorded in 1960 as an a cappella demo sent to Art Rupe. It became famous after it was recorded by the singer-songwriter-pianist Ray Charles with The Raelettes vocalist Margie Hendricks.

Charles's recording hit number one for two weeks on the Billboard Hot 100, beginning on Monday, October 9, 1961. "Hit the Road Jack" won a Grammy award for Best Rhythm and Blues Recording. The song was number one on the R&B Sides chart for five weeks, thereby becoming Charles's sixth number one on that chart. The song is ranked number 387 on Rolling Stone magazine's list of "The 500 Greatest Songs of All Time".

In 1976, Canadian band the The Stampeders released a version of the song featuring DJ Wolfman Jack. The song was a hit, reaching number 6 in Canada and the top 40 in the US.

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