The history of Christianity during the Middle Ages is the history of Christianity between the Fall of Rome (c. 476) and the onset of the Protestant Reformation during the early 16th century, the development usually taken to mark the beginning of modern Christianity. This is the period in European history known as the Middle Ages or Medieval era.
Among the dioceses, five held special eminence: Rome, Constantinople, Jerusalem, Antioch, and Alexandria, generally referred to as the Pentarchy. The prestige of most of these sees depended in part on their apostolic founders, or in the case of Byzantium/Constantinople, that it was the new seat (New Rome) of the continuing Roman or Byzantine Empire. These bishops considered themselves the spiritual successors of those apostles. In addition, all five cities were Early centers of Christianity.
The Early Middle Ages commenced with the deposition of the last Western Roman emperor in 476, to be followed by the barbarian king, Odoacer, to the coronation of Charlemagne as "Emperor of the Romans" by Pope Leo III in Rome on Christmas Day, 800. The year 476, however, is a rather artificial division. In the East, Roman imperial rule continued through the period historians now call the Byzantine Empire. Even in the West, where imperial political control gradually declined, distinctly Roman culture continued long afterwards; thus historians today prefer to speak of a "transformation of the Roman world" rather than a "fall of the Roman Empire." The advent of the Early Middle Ages was a gradual and often localised process whereby, in the West, rural areas became power centres whilst urban areas declined. With the Muslim invasions of the seventh century, the Western (Latin) and Eastern (Greek) areas of Christianity began to take on distinctive shapes. Whereas in the East the Church maintained its structure and character and evolved more slowly, in the West the Bishops of Rome (i.e., the Popes) were forced to adapt more quickly and flexibly to drastically changing circumstances. In particular whereas the bishops of the East maintained clear allegiance to the Eastern Roman Emperor, the Bishop of Rome, while maintaining nominal allegiance to the Eastern Emperor, was forced to negotiate delicate balances with the "barbarian rulers" of the former Western provinces. Although the greater number of Christians remained in the East, the developments in the West would set the stage for major developments in the Christian world during the later centuries.