After the fall of Tiwanaku empire, the many Aymara Lake Titicaca were conquered by the Inca empire. Prior to the Spanish conquest, the Andean province of Qullasuyu was a part of the Inca empire, while the northern and eastern lowlands were inhabited by independent nomadic tribes. Spanish conquistadors, arriving from Cuzco and Asunción took control of the region in the 16th century. During most of the Spanish colonial rule, Bolivia was known as Upper Peru and administered by the Royal Audiencia of Charcas. After the first call for independence in 1809, 16 years of war followed before the establishment of the Bolivian Republic, named for the Liberator Simón Bolívar, on August 6, 1825. Since then Bolivia has endured regular periods of political and economic instability, including the loss of various provinces to its neighbors, such as Acre, parts of the Gran Chaco and its Pacific coast, making it a land-locked country.
Cultures of indigenous peoples in Bolivia developed in the high altitude settings of altiplano with low oxygen lewels, poor soils and extreme weather patterns. The better suited lowlands were sparsely inhibited by hunter-gatherer societies while much of the pre-Columbian population was concentrated in altiplano valleys of Cochabamba and Chuquisaca.
Potato was domesticated near lake Titicaca between 8000 and 5000 BC, quinoa some 3000–4000 years ago and production of copper began in 2000 BC. Llama, alpaca and vicuña were domesticated and used for transport, food and clothing.