Heterokaryotic

A heterokaryon is a multinucleate cell that contains genetically different nuclei. Heterokaryotic and heterokaryosis are derived terms. This is a special type of syncytium. This can occur naturally, such as in the mycelium of fungi during sexual reproduction, or artificially as formed by the experimental fusion of two genetically different cells, as e.g., in hybridoma technology.

A medical example is a heterokaryon composed of nuclei from Hurler syndrome and Hunter syndrome. Both of these diseases result in problems in mucopolysaccharide metabolism. However, a heterokaryon of nuclei from both of these diseases exhibits normal mucopolysaccharide metabolism, proving that the two syndromes affect different proteins and so can correct each other in the heterokaryon.

Heterokaryons are found in the life cycle of yeasts, for example Saccharomyces cerevisiae, a genetic model organism. The heterokaryon stage is produced from the fusion of two haploid cells. This transient heterokaryon can produce further haploid buds, or cell nuclei can fuse and produce a diploid cell, which can then undergo mitosis.

The term heterokaryon was coined in 1965, independently by B. Ephrussi and M. Weiss, by H. Harris and J. F. Watkins, and by Y. Okada and F. Murayama.

The term was first used for ciliate protozoans such as Tetrahymena. This has two types of cell nuclei, a large, somatic macronucleus and a small, germline micronucleus. Both exist in a single cell at the same time and carry out different functions with distinct cytological and biochemical properties.

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