Sir Henry Vaughan the elder (by 1586 – 1660/61?) was a Welsh politician who sat in the House of Commons variously between 1621 and 1644. He was a Royalist leader during the English Civil War.
Vaughan was the sixth son of Walter Vaughan of Golden Grove, and his first wife Mary, daughter of Griffith Rice of Newton, Llandefaisant, Carmarthenshire. His date of birth is unknown, but assuming him to have been at least 21 in 1607, when he is recorded to have been appointed a deputy-coroner, he had been born by at least 1586. He was a younger brother of John Vaughan, 1st Earl of Carbery, and William Vaughan. Henry Vaughan married, at some point between 1609 and 1610, Sage, the daughter and heiress of John Gwyn William of Derwydd, Llandybie in Carmarthenshire, and the widow of Edward Rice of Newton. Vaughan settled at his wife's estates at Derwydd.
In 1620, he was High Sheriff of Carmarthenshire. In 1621 he was elected Member of Parliament for Carmarthen, and was returned again in 1624. The 1625 election was a confused affair. Vaughan was returned for the third time for Carmarthen, as witnessed by the mayor and members of the common council. But shortly afterwards another return was made out in favour of Sir Francis Annesley, the Principal Secretary of Ireland. Vaughan was one of those who witnessed Annesley's return, probably indicating that he intended to stand aside on Annesley's behalf. Vaughan's name in the Crown Office list, which had been entered after his initial return, was duly erased on receipt of Annesly's return, but Annesley's name did not replace it. This was presumably because parliament was dissolved before a final judgement could be made. Vaughan was returned without incident at the 1626 election, and again in 1628, sitting until 1629 when King Charles decided to rule without parliament.