Helicase-primase complex

A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.

The complex is used by herpesviruses in which it is responsible for lytic DNA virus replication. In many dsDNA viruses primase and helicase are fused into a single polypeptide, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively. A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.

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