Hekuran Isai (7 May 1933 in Peqin – 26 March 2008 in Tirana) was an Albanian politician of the Albanian Party of Labour (PPSh).
After joining the Albanian Party of Labour (Alb: Partia e Punes së Shqipërisë) in 1957, he studied in the Soviet Union from 1957 to 1960. On his return Isai served as a specialist in a petroleum refinery in Cërrik. In 1962, he was elected first-deputy of the People's Assembly (Alb: Kuvendi Popullor), and was also elected as a member of the parliament from the fifth until the end of the eleventh legislative, ending in 1991. He served initially as member of the Committee on Industry, Mining and Construction.
At the 5th Congress of the Party in November 1966, he was elected first-candidate of the Central Committee (CC) of the Party. In 1967 he started studying at the Party's School "Vladimir Ilyich Lenin" in Tirana, majoring in Political Economy.
Isai worked afterwards as First Secretary of the PPSh in Elbasan District, which at that time included his native town of Peqin, later as First Secretary in Librazhd District from 1970 to 1975, and for a short time First Secretary of the Party in the Dibër District. At the 6th Party Congress in November 1971, he was also elected a member of the Central Committee.
In June 1975, he became a member of the Secretariat of the Central Committee of the PPSh, and held this function until November 1986. A few months later, in September 1975, he was elevated as member of the Politburo of the Party, as substitute for the recently purged Deputy Prime Minister and Chairman of the State Planning Commission Abdyl Këllezi. Isai, together with Qirjako Mihali, Pali Miska, and Llambi Gegprifti, represented a new generation of leaders within the Party, which emerged with the termination of relations with the People's Republic of China.