"Heart and Soul" is a popular song, with music by Hoagy Carmichael and lyrics by Frank Loesser, published in 1938. The original 1938 version was performed by Larry Clinton & his Orchestra featuring Bea Wain.

In 1939, three versions charted: Larry Clinton (reaching #1 on the chart), Eddy Duchin (reaching #12), and Al Donahue (reaching #16). The song later charted as #11 in 1952 by The Four Aces with the Jack Pleis Orchestra, and as #57 in 1956 by Johnny Maddox. Two different cover versions charted in 1961, with The Cleftones reaching #18 and Jan and Dean reaching #25. Many covers have been recorded and it has been used in advertisements.

The band Train used the melody as a basis for their 2017 single "Play That Song".

The song's A-section is often simplified as a repeating I-vi-IV-V progression and taught to beginning piano students as an easy two-hand duet ( example ). Much like the piece "Chopsticks", this (somewhat inaccurate) version became widely known, even to those who never studied piano. The chord progression, often referred to as the "50s progression", was later employed in the doo-wop hits of the 1950s and 1960s.

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