"Heart Don't Lie" is a song by American singer La Toya Jackson. The song is the second single from her successful album Heart Don't Lie. It is a duet with singer Howard Hewett, although he receives no credit for his vocals in the liner notes and does not appear in the music video. Musical Youth and Janet Jackson also provide vocals for the track. The single peaked at #56 on the Billboard Hot 100 chart.

A 7" single was released with the track "Without You" for a B-side; the 12" maxi single included a Club Version and Dub Mix.

"Heart Don't Lie" was La Toya Jackson's first single to have an accompanying music video. It was directed by Ed Pacio in February 1984 in Los Angeles, California. The music video features Jackson in a very colorful and cartoon-like high school setting based on the 1978 film Grease. The clip utilizes Carnival masks designed by Joseph McLaughlin. It also features The Mums, a trio of jugglers and magicians that included Albie Selznick. "Heart Don't Lie" was one of the subjects of VH1's "Pop-Up Video" in 1997.

Jackson performed "Heart Don't Lie" on the 30 June 1984 episode of American Bandstand. The number was also performed on the August 25, 1984 episode of Solid Gold along with Hewett. The track appeared in Jackson's advert for Nikon cameras.

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