Hazel Run is an unincorporated community in St. Francois County, in the U.S. state of Missouri.
A post office called Hazel Run was established in 1844, and remained in operation until 1928. The community takes its name from nearby Hazel Run creek.
Coordinates: 37°56′49″N 90°27′56″W / 37.94694°N 90.46556°W