Hattusili II (Hittite: "from Hattusa") may have been a king of the Hittite Empire (New kingdom) ca. the early 14th century BC (short chronology).
His existence is disputed. In the treaty between Muwatalli II and Talmi-Šarruma of Aleppo, reference is made to a ruler named Hattusili, but it is debated whether the reference is to an otherwise unknown Hittite ruler, or rather to Hattusili I.