Johannes Otto Kehr (April 27, 1862 – May 20, 1916) was a German surgeon and professor of surgery born in Waltershausen, Thuringia.
He practiced surgery at a private clinic in Halberstädt, and from 1910 worked in Berlin. He is known for the development of operative procedures for the treatment of gall bladder and bile duct diseases.
In the late 19th century, Kehr popularized the cholecystectomy for the treatment of gallstones. He is credited with performing 2600 operations of the biliary tract during his career.
His name is lent to Kehr's sign, which is in an indication of acute pain in the left shoulder associated with a ruptured spleen. Also, he popularized a device for biliary drainage that today is known as "Kehr's T-tube".