Hanabusa Domain (花房藩 Hanabusa-han?) was a Japanese feudal domain of the early Meiji period, located in Nagasa District, Awa Province. It was centered at what is now the Yokosuka (横渚?) area of the city of Kamogawa in modern Chiba Prefecture.
In 1867, during the Meiji Restoration, the final Shogun, Tokugawa Yoshinobu resigned his office to Emperor Meiji and leadership of the Tokugawa clan to Tokugawa Iesato. In 1868, Iesato was demoted in status to that of an ordinary daimyō, and assigned the newly created Shizuoka Domain, which included all of former Sunpu Domain, neighboring Tanaka and Ojima Domains, and additional lands in Tōtōmi and Mutsu Provinces for a total revenue of 700,000 koku. The new domain covered the western two-thirds of Shizuoka Prefecture, plus the Chita Peninsula in Aichi Prefecture.