HHV-5
| Cytomegalovirus | |
|---|---|
| Classification and external resources | |
| Specialty | infectious disease |
| ICD-10 | B25 |
| ICD-9-CM | 078.5 |
| MedlinePlus | 000568 |
| Patient UK | Cytomegalovirus |
| MeSH | D003586 |
| Cytomegalovirus | |
|---|---|
 |
|
| Typical "owl eye" inclusion indicating CMV infection of a lung pneumocyte | |
| Virus classification | |
| Group: | Group I (dsDNA) |
| Order: | Herpesvirales |
| Family: | Herpesviridae |
| Subfamily: | Betaherpesvirinae |
| Genus: | Cytomegalovirus |
| Type species | |
|
Human cytomegalovirus |
|
Cytomegalovirus (CMV) (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family(150-200nm in diameter[hiv virus 120nm]) Herpesviridae, in the subfamily Betaherpesvirinae. Humans and monkeys serve as natural hosts. There are currently eight species in this genus including the type species, human cytomegalovirus (HCMV, human herpesvirus 5, HHV-5), which is the species that infects humans. Diseases associated with HHV-5 include glandular fever, and pneumonia. In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses.
Cytomegalovirus was first observed by German pathologist Hugo Ribbert in 1881 when he noticed enlarged cells with enlarged nuclei present in the cells of an infant.
Within Herpesviridae, CMV belongs to the Betaherpesvirinae subfamily, which also includes the genera Muromegalovirus and Roseolovirus (HHV-6 and HHV-7). It is related to other herpesviruses within the subfamilies of Alphaherpesvirinae that includes herpes simplex viruses (HSV)-1 and -2 and varicella-zoster virus (VZV), and the Gammaherpesvirinae subfamily that includes Epstein–Barr virus.
Group: dsDNA
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