Guy de Bryan, 1st Baron Bryan, KG (born before 1319, died 17 August 1390) was an English soldier.
He was the son of Sir Guy de Bryan (d.1349) (alias de Brienne), of Walwyn's Castle in Pembrokeshire and Torbryan in Devon.
He served on the English side in the Second War of Scottish Independence and in France and Flanders during the Hundred Years' War. In 1341 he was made Warden of the Forest of Dean, in Gloucestershire, and Governor of St Briavel's Castle, the seat of the Warden, which offices he held until his death. In 1349 he was temporarily Keeper of the Great Seal of England, and in 1350 was granted an annuity of 200 marks for bearing the King's Standard against the French at Calais. From 25 November 1350 he was summoned to Parliament and may thereby be held to have been created Baron Bryan. In 1361 he was Ambassador to Pope Innocent VI, and in 1369 was Admiral of the Fleet. Following the death of Sir John Chandos on 31 December 1369 he was made a Knight of the Garter.
He married twice and left issue by his second wife only:
Bryan on 17 August 1390. He was buried with his second wife, who had died in 1359, in Tewkesbury Abbey, Gloucestershire.