Guaiphenesin
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| Clinical data | |
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| Trade names | Mucinex |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682494 |
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| Routes of administration |
Oral |
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| Pharmacokinetic data | |
| Metabolism | Renal |
| Biological half-life | 1-5 hours |
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| ChEMBL | |
| ECHA InfoCard | 100.002.021 |
| Chemical and physical data | |
| Formula | C10H14O4 |
| Molar mass | 198.216 g/mol |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Guaifenesin INN /ɡwaɪˈfɛnᵻsɪn/ or guaiphenesin (former BAN), also glyceryl guaiacolate, is an expectorant drug sold over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from the airways in acute respiratory tract infections.
Guaifenesin is used to control cough and is sometimes combined with dextromethorphan, an antitussive, such as in Mucinex DM or Robitussin DM.
A 2008 Cochrane Collaboration meta-analysis of over-the-counter medicines for acute cough in children and adults concluded that there was not enough high-quality clinical data to prove whether it is effective or not.
Side-effects of guaifenesin include nausea, vomiting, formation of kidney stones, diarrhea, and constipation. Nausea and vomiting can be reduced by taking guaifenesin with meals. The risk of forming kidney stones during prolonged use can be reduced by maintaining good hydration and increasing the pH of urine. Rarely, severe allergic reactions may occur, including a rash or swelling of the lips or face, which may require urgent medical assistance. Mild dry mouth or chapped lips may also occur when taking this medication. Drinking a glass of water is recommended with each dose of guaifenesin.
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Wikipedia