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Guaiphenesin

Guaifenesin
Guaifenesin.svg
Clinical data
Trade names Mucinex
AHFS/Drugs.com Monograph
MedlinePlus a682494
License data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Renal
Biological half-life 1-5 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.002.021
Chemical and physical data
Formula C10H14O4
Molar mass 198.216 g/mol
3D model (JSmol)
Chirality Racemic mixture
  

Guaifenesin INN /ɡwˈfɛnsɪn/ or guaiphenesin (former BAN), also glyceryl guaiacolate, is an expectorant drug sold over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from the airways in acute respiratory tract infections.

Guaifenesin is used to control cough and is sometimes combined with dextromethorphan, an antitussive, such as in Mucinex DM or Robitussin DM.

A 2008 Cochrane Collaboration meta-analysis of over-the-counter medicines for acute cough in children and adults concluded that there was not enough high-quality clinical data to prove whether it is effective or not.

Side-effects of guaifenesin include nausea, vomiting, formation of kidney stones, diarrhea, and constipation. Nausea and vomiting can be reduced by taking guaifenesin with meals. The risk of forming kidney stones during prolonged use can be reduced by maintaining good hydration and increasing the pH of urine. Rarely, severe allergic reactions may occur, including a rash or swelling of the lips or face, which may require urgent medical assistance. Mild dry mouth or chapped lips may also occur when taking this medication. Drinking a glass of water is recommended with each dose of guaifenesin.


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Wikipedia

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