The Union de pharmacologie scientifique appliquée (UPSA) was a French pharmaceutical group independent from 1935 to 1994, till acquisition by Bristol Myers Squibb.
It was founded in Agen in 1935 by Dr Camille Bru. Following the founder's death in 1958 the group was run by his son Jean Bru till his own death 1989, and then by Jean Bru's widow Nicole Bru, née Magniez, from 1989 till 1994. The Fondation Bru administers the charitable and cultural interests of the family.