Griffiths Mxenge, (27 February 1935 – 19 November 1981) was a South African anti-apartheid activist. Trained as a lawyer, he was assassinated by the apartheid secret police in 1981. He was a member of the African National Congress (ANC). He was sent to Robben Island in 1966 because of his political activities. He was murdered by the Apartheid government agents led by Dirk Coetzee in Umlazi township south of Durban. He had multiple stab wounds and his body was found near the soccer field in Umlazi.
He was married to Victoria Mxenge, who was later also assassinated.