Greek National Road 53 is a national highway of Greece. It connects Alexandroupoli with Ormenio on the Bulgarian border, passing through Aisymi, Mikro Dereio, Metaxades and Kyprinos.
Coordinates: 41°14′04″N 26°02′23″E / 41.2345°N 26.0397°E / 41.2345; 26.0397