"Great Balls of Fire" is a 1957 popular song recorded by Jerry Lee Lewis on Sun Records and featured in the 1957 movie Jamboree. It was written by Otis Blackwell and Jack Hammer. The Jerry Lee Lewis 1957 recording was ranked as the 96th greatest song ever by Rolling Stone. The song is in AABA form. The song sold one million copies in its first 10 days of release in the United States and sold over five million copies, making it both one of the best-selling singles in the United States, as well as one of the world's best-selling singles of all time.

The song is best known for Jerry Lee Lewis's original recording, which was recorded in the Sun Studio in Memphis, Tennessee, on October 8, 1957, using Roland Janes on guitar and JM Van Eaton on drums. It was released as a 45rpm single on Sun 281 in November 1957. It reached No. 2 on the Billboard pop charts, No. 3 on the R&B charts, and No. 1 on the country charts. It also reached No. 1 on the UK Singles Chart, appeared on the New Zealand Singles Chart, and the Dutch Top 40.

The song was featured in a performance by Jerry Lee Lewis and his band in the 1957 Warner Brothers rock and roll film Jamboree, which also featured Carl Perkins, Fats Domino, Buddy Knox, and Dick Clark. The recording was also released in the UK on London Records.

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