Grape Grove is an unincorporated community in Greene County, in the U.S. state of Ohio.
Grape Grove was not officially platted. A post office called Grape Grove was established in 1850, the name was changed to Grapegrove in 1895, and the post office closed in 1906.
John Little, a member of the U.S. House of Representatives from Ohio's 8th district, was born near Grape Grove in 1837.
Coordinates: 39°42′59″N 83°40′54″W / 39.71639°N 83.68167°W