The Grand Duchy of Mecklenburg Friedrich-Franz Railway (Großherzoglich Mecklenburgische Friedrich-Franz-Eisenbahn or M.F.F.E.) was the state railway company in Mecklenburg-Schwerin and Mecklenburg-Strelitz. After its second nationalisation in 1890 up to the merger of the Länderbahnen into the Deutsche Reichsbahn in 1920 it was under the direction of the Grand Duchy's Executive Railway Board (Großherzoglichen General-Eisenbahndirection or GGED) in Schwerin.
Mecklenburg is a region in northern Germany comprising the western and larger part of the present day state of Mecklenburg-Vorpommern. Its largest cities are , Schwerin, and Neubrandenburg. In 1815, the two Mecklenburg duchies - Grand Duchy of Mecklenburg-Schwerin and Mecklenburg-Strelitz - were raised to Grand Duchies, and subsequently existed separately in Germany until the end of World War I. The earlier private railways were nationalised by 1890 into the Grand Duchy of Mecklenburg Friedrich-Franz Railway.
The first railway route in Mecklenburg was the Prussian Berlin–Hamburg line, which opened in 1846. As a result, stations appeared in Ludwigslust and Hagenow and other places. On 10 March 1846 the Mecklenburg Railway Company was given the concession to build a route from Hagenow to Schwerin and on to Wismar, and with a branch to Güstrow. On 13 May 1850 the line was finished.