There are 48 Grade I listed buildings in Greater Manchester, England. In the United Kingdom, the term listed building refers to a building or other structure officially designated as being of special architectural, historical or cultural significance; Grade I structures are those considered to be "buildings of exceptional interest". In England, the authority for listing under the Planning (Listed Buildings and Conservation Areas) Act 1990 rests with Historic England, a non-departmental public body sponsored by the Department for Culture, Media and Sport.
The metropolitan county of Greater Manchester is made up of 10 metropolitan boroughs: Bolton, Bury, Manchester, Oldham, Rochdale, Salford, , Tameside, Trafford and Wigan. The Grade I buildings in each borough are listed separately. Manchester, the world's first industrialised city, has 15 of Greater Manchester's 45 Grade I listed buildings, the highest number of any borough. Oldham is the only borough to have no listed buildings with a Grade I rating. The River Irwell forms the boundary between Manchester and Salford, so one listed structure, the railway bridge over the Irwell, has been listed under both Manchester and Salford.