"Got My Mind Set on You" is a song written and composed by Rudy Clark and originally recorded by James Ray in 1962, under the title "I've Got My Mind Set on You". An edited version of the song was released later in the year as a single on the Dynamic Sound label. In 1987, George Harrison released a cover version of the song as a single, and released it on his album, Cloud Nine, which he had recorded on his own Dark Horse Records label.

Of Harrison's three number-one singles in the US, it was both the only song not written or composed by Harrison himself and the only one without religious overtones. It also was not only the last US number 1 hit by Harrison, but also from any of the ex-Beatles in the US. When the song hit number 1, it broke a three-way tie among Harrison, John Lennon, and Ringo Starr, all of whom had two number 1 hit singles as solo artists (discounting Paul McCartney's work with Wings). It also happened to be the number 1 single in the US the week immediately preceding the induction of The Beatles into the Rock and Roll Hall of Fame, making Harrison one of the few inductees to have an active single on the US record charts at the time of induction. Billboard ranked it as the No. 3 song for 1988.

The single's B-side is "Lay His Head", a remixed version of the unreleased song from Harrison's originally intended Somewhere in England album. The 12-inch version of the single also adds an extended version of "Got My Mind Set on You".

In the UK the single spent four weeks at number two. It was kept off the number 1 spot by T'Pau's "China in Your Hand".

The song was included in the Harrison compilation albums Best of Dark Horse 1976–1989 (1989) and Let It Roll: Songs by George Harrison (2009).

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