Gold sodium thiomalate

Sodium aurothiomalate
Clinical data

Trade names	Myocrisin
AHFS/Drugs.com	Multum Consumer Information
License data	US FDA: Gold_sodium_thiomalate
Pregnancy category	AU: B2 US: C (Risk not ruled out)
Routes of administration	Intramuscular
ATC code	M01CB01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	High
Biological half-life	6-25 days
Excretion	Urine (60-90%), faeces (10-40%)
Identifiers
IUPAC name Sodium 2-(auriosulfanyl)-3-carboxypropanoate
CAS Number	12244-57-4
PubChem CID	16760302
ChemSpider	7827788^Y
UNII	E4768ZY6GM
ChEBI	CHEBI:35863^Y
Chemical and physical data
Formula	C₄H₄AuNaO₄S
Molar mass	367.939350590
3D model (JSmol)	Interactive image
SMILES [Au+].[Na+].[O-]C(=O)C([S-])CC(=O)O
InChI InChI=1S/C4H6O4S.Au.Na/c5-3(6)1-2(9)4(7)8;;/h2,9H,1H2,(H,5,6)(H,7,8);;/q;2*+1/p-2^Y Key:LTEMOXGFFHXNNS-UHFFFAOYSA-L^Y

Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Along with an orally-administered gold salt, auranofin, it is one of only two gold compounds currently employed in modern medicine.

It is primarily given once or twice weekly by intramuscular injection for moderate-severe rheumatoid arthritis although it has also proven itself effective in treating tuberculosis.

Its most common side effects are digestive (mostly dyspepsia, mouth swelling, nausea, vomiting and taste disturbance), vasomotor (mostly flushing, fainting, dizziness, sweating, weakness, palpitations, shortness of breath and blurred vision) or dermatologic (usually itchiness, rash, local irritation near to the injection site and hair loss) in nature, although conjunctivitis, blood dyscrasias, kidney damage, joint pain, muscle aches/pains and liver dysfunction are also common. Less commonly, it can cause GI bleeds, dry mucous membranes and gingivitis. Rarely it can cause: aplastic anaemia, ulcerative enterocolitis, difficulty swallowing, angiooedema, pneumonitis, pulmonary fibrosis, hepatotoxicity, cholestatic jaundice, peripheral neuropathy, Guillain–Barré syndrome, encephalopathy, encephalitis and photosensitivity.

...
Wikipedia