"Give It Up to Me" is a song by Colombian singer-songwriter Shakira featuring American rapper Lil Wayne, taken from the deluxe version of the former's eighth studio album She Wolf. It was released on 19 October 2009, by Epic Records as the third single from the album. The song was written by Shakira, Amanda Ghost, Dwayne Carter and Timbaland. Timbaland also served as the producer of the song. Musically, "Give It Up to Me" is a synthpop and hip hop song that incorporates sexually-suggestive lyrics. The song features uncredited vocals from Timbaland

Upon its release, the song received generally favorable reviews from music critics, who appreciated its production and the collaboration with Lil Wayne and Timbaland. It peaked at number twenty-nine on the US Billboard Hot 100, and was later certified gold by the Recording Industry Association of America (RIAA). Elsewhere, the song attained moderate success in Australia, Canada, and Europe. Its accompanying music video was directed by Sophie Muller and premiered on 17 November 2009. It received mixed reviews from critics, who were ambivalent towards its choreography and production.

"Give It Up to Me" was written by Shakira, Amanda Ghost, Lil Wayne, and Timbaland, and was produced by the latter. Timbaland, who produced "Give It Up to Me", initially planned to include the song on his third studio album Shock Value II (2009). He originally served as the featured vocalist, though his verse was replaced by Flo Rida, who himself was later substituted by Lil Wayne. Amanda Ghost, the president of Epic Records, noted that "everyone's breath was blown away" when Lil Wayne expressed interest in appearing on the track. The last-minute collaboration resulted in the delayed release of its parent album She Wolf in the United States. The decision resulted in the creation of a deluxe version of the album available exclusively in the country.

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