"Give It Up or Turnit a Loose" is a funk song recorded by James Brown. Released as a single in 1969, the song was a #1 R&B hit and also made the top 20 pop singles chart. "Give It Up or Turnit a Loose" appeared as an instrumental on the Ain't It Funky album, removing Brown's vocals and adding guitar overdubs.

"The original 'Give It Up or Turnit a Loose' appeared as a single in early '69, arranged by the '60's bandleader 'Pee Wee' Ellis. A year later, reinvigorated by his new band, Mr. Brown would readdress 'Give It Up.' Where the original version percolated with jazzy overtones, this revisit was kinetic, raw, uncut. This monster funk bomb exploded in the underground in '73, when a young Bronx DJ named Kool DJ Herc would load on the turntables two copies of the Sex Machine album and between them he would run an extended cut 'n' mix of the percussion breakdown. Hip-hop was born. The shockwaves have been felt ever since"

Brown recorded "Give It Up or Turnit a Loose" again with The J.B.'s for his 1970 double album Sex Machine. Over five minutes long, this later recording used a substantially different instrumental arrangement, with an added organ riff and a florid bassline, as well as different lyrics. A remix of this recording by Tim Rogers appears on the 1986 compilation album In the Jungle Groove. The remixed version has been extensively sampled. A genuine live version of the song appears on the album Live at Chastain Park.

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