Girolamo Scotto (Hieronymus Scotus; also Gerolamo) (c.1505 – 3 September 1572) was an Italian printer, composer, businessman and bookseller of the Renaissance, active mainly in Venice. He was the most influential member of the firm of Venetian printers, the House of Scotto, which existed from the late 15th century until 1615. At its peak in the 1560s, the Scotto firm under Girolamo was one of the preeminent publishing firms of Europe, producing volumes on law, scholasticism, philosophy, medicine, theology, and ancient literature in addition to music. Only the firm of Gardano produced more books of music in the 16th century than the House of Scotto under Girolamo; over half of Scotto's publications, 409 out of approximately 800 in total, were books of music.
Girolamo was one of six children of Bernardino Scotto, of Milan (1447–1537). Born in Milan, his early life is undocumented, and prior to the first appearance of his name on a Scotto-published book in 1539, his name appears only once in the historical record: in a petition to the Venetian Senate dated 1536 requesting a printing privilege for a work of scholastic philosophy by Marcantonio Zimara on Averroes' commentaries on Aristotle. He married Cesaria Sinistri, who survived him, as she was the executor of his will; they probably had no children. Most likely he was involved in the firm during the 1530s, learning both the craft and the trade. Some Scotto-published books of madrigals of Philippe Verdelot – dated 1536 and 1538 – show idiosyncrasies associated with Girolamo's later work, and may have been typeset by him.
In 1539 Girolamo took over operation of the family business from his brother Ottaviano II. While Ottaviano lived until at least 1566, he seems to have had little further control over the firm, although he continued to publish. In her book on the Scotto firm, Jane Bernstein suggests that Ottaviano may have been ill, since he made two separate wills in the 1540s; he also may have preferred to devote his time to his other interests, such as philosophy and medicine, happily giving over the business aspect of the publishing house to his younger brother. Girolamo acquired control of the publishing house at a singularly opportune time. Venice was entering into a several-decade-long period of peace and prosperity, and capitalist, commercial enterprises were doing well. There was an enormous demand for madrigals, a relatively new musical form proving immensely popular in Italy, and through the technological advance of single-impression music printing – in which blocks of type imprinted a portion of staff along with a note – Girolamo was able to mass-produce music to meet the market demand. In addition to producing music books he also continued the firm's tradition of publishing other subjects, such as philosophy, medicine, law, theology, and other matters, and all the while composing and publishing his own music.