"Girls, Girls, Girls" is the second single from rapper Jay-Z's album The Blueprint. It is a playful description of the artist's promiscuous lifestyle. The song contains a sample of "There's Nothing In This World That Can Stop Me From Loving You" by Tom Brock. The chorus features a lyrical interpolation of "High Power Rap" by Crash Crew. The song has additional vocals sung by Q-Tip, Slick Rick and Biz Markie, but they are not credited as featured guests on the back artwork; they are, however, credited in the album's liner notes.

A remix of the song produced by Kanye West can be found as a hidden track on The Blueprint after the songs "Blueprint (Momma Loves Me)" and the other hidden song "Lyrical Exercise". The remix is composed of new verses by Jay-Z, a new instrumental sampling "Trying Girls Out" by The Persuaders and uncredited vocals from Michael Jackson and Chante Moore. Just Blaze originally produced the song for Ghostface Killah.

The video was filmed in September 2001 in Los Angeles, California. Jay-Z stated in a 2011 interview that he was in Los Angeles preparing for the shoot when the September 11 terrorist attacks took place:

I flew to L.A. I was shooting a video for a song called 'Girls, Girls, Girls,'" he began. "I'd dropped my album The Blueprint on the same day. And I just remember waking up in LA and thinking everybody was playing, like 'That can't be,' then turning on the TV and it looked like something from one of those apocalyptic movies.

Actresses Carmen Electra, Tamala Jones, and Paula Jai Parker, all make cameo appearances in the song's music video. Damon Dash, Biz Markie, and Kanye West also make brief appearances in the video.

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