Giovanni Sante Gaspero Santini (b. Caprese in Tuscany, 30 Jan., 1787; d. Noventa Padovana, 26 June 1877) was an Italian astronomer and mathematician.
He received his first instruction from his parental uncle, the Abbot Giovanni Battista Santini. After finishing his philosophical studies in the school year 1801-2, at the seminary of Prato, he entered in 1802 the University of Pisa. He very soon abandoned the study of law in order to devote himself, under the direction of Prof. Paoli and Abbot Pacchiano, exclusively to mathematics and the natural sciences. It appears that at Pisa, Santini still wore the cassock, with the consequence that in bibliographical dictionaries he still figures under the title of abate. It is certain, however, that he never received major orders.
In 1810 he married Teresa Pastrovich, and one year after her death, in 1843, he contracted a second marriage with Adriana Conforti, who outlived him. During his stay in Pisa he became friendly with the rector of the university and of the influential Vittorio Fossombroni. At their urgent suggestion Santini's family, especially his uncle, made great sacrifices to enable him to continue his studies in Milan (1805–1806) under Barnaba Oriani, Cesaris, and Francesco Carlini. On 17 Oct., 1806, the Italian Government appointed him assistant to the director of the observatory at Padua, Abate Chiminello, whom he succeeded in 1814. In 1813 the university offered him the chair of astronomy, a position in which he was confirmed by the Emperor Francis I in 1818 after the Venetian territory had become part of Austria. In addition he taught for several years, as substitute, elementary algebra, geometry, and higher mathematics. During the school years 1824-1825 and 1856-1857 he was rector of the university, and from 1845 to 1872 director of mathematical studies. Towards the end of 1873 he suffered repeatedly from fainting spells which were followed by a steadily increasing physical and mental weakness and final breakdown. He died in his ninety-first year at his villa, Noventa Padovana.