George Skene Duff (1814 – 12 March 1889) was a Scottish politician, the son of Sir Alexander Duff.
He served as Member of Parliament (MP) for Elgin Burghs from 1847 to 1857. He was the younger brother of James Duff, 5th Earl Fife, who sat in Parliament at the same time, representing Banffshire. He was Lord Lieutenant of Elginshire from 1856 until 1872.