George Seton V, 7th Lord Seton (1531–1586) was a Lord of the Parliament of Scotland, Master of the Household of Mary, Queen of Scots and Provost of Edinburgh. He was the eldest son of George Seton, 6th Lord Seton and Elizabeth Hay, a daughter of John Hay, 3rd Lord Hay of Yester. His childhood and schooling were in France.
George Seton was Provost of Edinburgh in 1557, and from time to time would send his carpenter, Robert Fendour, to the Burgh Council as his representative. In February 1558, George Seton was one of eight commissioners sent to Henry II of France to negotiate the marriage of Mary, Queen of Scots, to the Dauphin. On 29 November 1558, the Parliament of Scotland granted that Seton and the others had fulfilled their commission. In February 1559, the town council gave him funds to prepare a banquet for Mary of Guise on their behalf.
However, Seton and the burgh council began to encounter difficulties, due only in part to the Scottish Reformation. Then, after rioting in Perth, Edinburgh was occupied by the Protestant Lords of the Congregation in June 1559. Seton tried unsuccessfully to protect the Blackfriars and Greyfriars monasteries. The Protestant Lords left Edinburgh in July, but made an agreement with Guise permitting freedom of conscience in religion. Seton, the Earl of Huntly and Châtellerault were asked to meet the people of Edinburgh to discuss the restoration of Mass in St Giles. According to John Knox, they met with refusal and the people would not allow the Mass in any other church. By the time the Lords of the Congregation occupied Edinburgh for the second time in October 1559, another rival council had already formed, led by Archibald Douglas of Kilspindie. The Protestant lords retreated and Seton's council was re-instated. When the English army mobilised by the Treaty of Berwick arrived in April 1560, Kilspindie's council was back in power.