Genesee College was founded as the Genesee Wesleyan Seminary, in 1831, by the Methodist Episcopal Church. The college was located in Lima, New York, and eventually relocated to Syracuse, becoming Syracuse University.
In 1831, the Genesee Wesleyan Seminary was founded in Lima, south of Rochester, by the Genesee Annual Conference of the Methodist Episcopal Church. The Rev. Dr. Samuel Luckey was elected the first Principal of the seminary, and was transferred from the New York Annual Conference to the Genesee Conference of the M.E. Church . He remained in office until 1836, when he was elected as editor of The Christian Advocate and Journal, an important periodical for the M.E. General Conference.
The institution is said to have "opened most favorably," with a total enrollment of 341 the first year (1831–32), with 170-180 students attending at any one time. The Agents of the seminary solicited funds for the construction of buildings. In 1880, Bishop Matthew Simpson of the M.E. Church described the seminary's early years thus "no other institution in the church accomplishing apparently more in the education of active and useful young men and young women." The early years of the institution were said to be ones of "great prosperity." This was especially true under the administrations of the Rev. Schuyler Seager. Seager was born 8 July 1807 in Simsbury, Connecticut. He joined the Genesee Conference in 1833. He graduated from Wesleyan University in 1836. That same year he was appointed Teacher of Moral Science and Belles-Lettres in the Genesee Wesleyan Seminary. He was chosen as Principal of the seminary in 1837. After entering pastoral ministry in 1844, he returned to the seminary in 1854, again as Principal.In 1856-57 he was made Principal of the Genesee Model School in Lima, New York, an offshoot of the seminary.Joseph Cummings was appointed President of Genesee in 1854, a position he held until 1857.
In 1850 it was resolved to enlarge the institution from a seminary into a college, or to connect a college with the seminary. The Rev. Dr. Benjamin Franklin Tefft was elected President of this endeavor. The name was chosen as Genesee College. However, the location was thought by many not to be sufficiently central. Its difficulties were compounded by the next set of technological changes: the railroad that displaced the Erie Canal as the region's economic engine bypassed Lima completely. In 1866, after several hard years, the trustees of the struggling college decided to seek a locale whose economic and transportation advantages could provide a better base of support. As Genesee College began looking for a new home, the bustling community of Syracuse, ninety miles to the east, was engaged in a search of its own. The rail age had expanded the prosperity brought by the Erie Canal, and the city was booming, but its citizens yearned for something more: