Terry Pratchett's fictional Discworld has a large number of creatures and plants unique to it or its parasite universes (such as Fairyland or Death's Domain).
A big cat with a unique black and white check coat, the ambiguous puzuma is the Disc's fastest animal. Due to the Disc's standing magical field, which slows down light to approximately the speed of sound, the puzuma can actually achieve near-light-speed. Therefore, seeing a puzuma in motion means it isn't there. Puzumas commonly die from complications caused by Sangrit Heisenberg's Uncertainty Principle; they lose concentration because they cannot simultaneously know who they are and where they are, frequently causing them to crash into an obstacle. Many males also die from ankle failure caused by excessively running after females who aren't present.
A giant and nearly extinct snake, seen in Sourcery. It has similar powers to a traditional basilisk, such as deadly venom and the ability to kill something by looking at it. When the basilisk in Sourcery met the Luggage, it attempted to stare the Luggage to death. However, thanks to the luggage's penetrating eyeless stare, the basilisk was unable to win the resulting staring contest, and was forced to blink. It was then killed by the Luggage.
A bookworm that has evolved in magical libraries. Because of the constant danger of running into a volume containing spells (which release thaumic radiation), the .303 caliber bookworm eats quickly. So quickly, in fact, that it has been known to ricochet off walls after boring through a shelf of books. It is the second fastest thing on the Disc (the fastest being Casanunda in a nunnery).
A parody of the chimera of Greek mythology, an archetypal Greek "hybrid monster". The Discworld chimera pastiches this by having, according to a bestiary quoted in Sourcery, "thee legges of a mermaide, the hair of a tortoise, the teeth of a fowel and the winges of a snake. Of course, I have only my worde for it, the beast having the breathe of a furnace and the temperament of a rubber balloon in a hurricane."