GM6001

GM6001

Names
IUPAC name (R)-N'-Hydroxy-N-[(S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl]-2-isobutylsuccinamide
Other names Galardin, GM6001
Identifiers
CAS Number	142880-36-2
3D model (JSmol)	Interactive image
Abbreviations	GM6
ChEBI	CHEBI:137236
ChemSpider	117009
DrugBank	DB02255
MeSH	GM6001
PubChem CID	132519
InChI InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
SMILES CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC
Properties
Chemical formula	C20H28N4O4
Molar mass	388.47 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Ilomastat (INN), also known as galardin or GM6001 is a broad-spectrum matrix metalloproteinase inhibitor.

Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.

Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis.